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This article discusses the discovery of phosphorescent lithopone on watercolor drawings by American artist John La Farge dated between 1890 and 1905 and the history of lithopone in the pigment industry in the late 19th and early 20th centuries. Despite having many desirable qualities for use in white watercolor or oil paints, the development of lithopone as an artists’ pigment was hampered by its tendency to darken in sunlight. Its availability to, and adoption by, artists remain unclear, as colormen's trade catalogs were generally not explicit in describing white pigments as containing lithopone. Further, lithopone may be mistaken for lead white during visual examination and its short-lived phosphorescence can be easily missed by the uninformed observer. Phosphorescent lithopone has been documented on only one other work-to-date: a watercolor by Van Gogh. In addition to the history of lithopone's manufacture, the article details the mechanism for its phosphorescence and its identification aided by Raman spectroscopy and spectrofluorimetry.
Titanium dioxide is a mineral that’s used as a white coloring in a variety of products, including sunscreens, cosmetics, paints, and plastics. The pigment grade is also known as titanium white, pigment white 6, or CI 77891; it's the whitest and brightest of all known pigments.
3. What is EFSA saying in its 2021 opinion on the safety of titanium dioxide as a food additive?

Titanium dioxide is an insoluble mineral, meaning it cannot dissolve in water. Known for its bright, white pigment, manufacturers use titanium dioxide in many different capacities, including in cosmetics, foods, and drugs.
Abbreviations

wholesale classification of calcium carbonate.
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Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.
So, what does it all mean for you, the consumer? Should you stop eating Skittles or begin checking foods for the presence of titanium dioxide? Here's a closer look.
A 2012 study published in the journal Environmental Science & Technology noted that children are especially exposed to titanium dioxide because of the food that contains the food additive and is particularly marketed to children, including candy and cakes.
Scrap zinc or concentrated zinc ores are dissolved in sulfuric acid, the solution is purified, and the two solutions are reacted. A heavy mixed precipitate results that is 28 to 30% zinc sulfide and 72 to 70% barium sulfate.
Additional information
Food additive or carcinogen? The growing list of chemicals banned in EU but used in US, by Mikaela Conley, The Guardian, June 23, 2022