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Different dermal cell types have been reported to differ in their sensitivity to nano-sized TiO2 . Kiss et al. exposed human keratinocytes (HaCaT), human dermal fibroblast cells, sebaceous gland cells (SZ95) and primary human melanocytes to 9 nm-sized TiO2 particles at concentrations from 0.15 to 15 μg/cm2 for up to 4 days. The particles were detected in the cytoplasm and perinuclear region in fibroblasts and melanocytes, but not in kerati-nocytes or sebaceous cells. The uptake was associated with an increase in the intracellular Ca2+ concentration. A dose- and time-dependent decrease in cell proliferation was evident in all cell types, whereas in fibroblasts an increase in cell death via apoptosis has also been observed. Anatase TiO2 in 20–100 nm-sized form has been shown to be cytotoxic in mouse L929 fibroblasts. The decrease in cell viability was associated with an increase in the production of ROS and the depletion of glutathione. The particles were internalized and detected within lysosomes. In human keratinocytes exposed for 24 h to non-illuminated, 7 nm-sized anatase TiO2, a cluster analysis of the gene expression revealed that genes involved in the “inflammatory response” and “cell adhesion”, but not those involved in “oxidative stress” and “apoptosis”, were up-regulated. The results suggest that non-illuminated TiO2 particles have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes in extracellular matrix remodelling. In human keratinocytes, Kocbek et al. investigated the adverse effects of 25 nm-sized anatase TiO2 (5 and 10 μg/ml) after 3 months of exposure and found no changes in the cell growth and morphology, mitochondrial function and cell cycle distribution. The only change was a larger number of nanotubular intracellular connections in TiO2-exposed cells compared to non-exposed cells. Although the authors proposed that this change may indicate a cellular transformation, the significance of this finding is not clear. On the other hand, Dunford et al. studied the genotoxicity of UV-irradiated TiO2 extracted from sunscreen lotions, and reported severe damage to plasmid and nuclear DNA in human fibroblasts. Manitol (antioxidant) prevented DNA damage, implying that the genotoxicity was mediated by ROS.
≤14
2. Cosmetics
Here, NaOH or NH3 · H2O is used as a precipitant or pH regulator to react with FeSO4 to form ferrous hydroxide precipitation; Air is used as oxidant; The iron sheet reacts with sulfuric acid produced during the oxidative hydrolysis of FeSO4 to provide ferrous ions required in the reaction system and maintain the pH value of the solution. The alkali consumption of acid method is less and the particles are easy to wash. The relative rates of seed preparation and crystal growth determine the particle size, particle size distribution and particle morphology of iron yellow particles.
Key benefits for stakeholders


While we have aimed to create an all-encompassing lithopone plant project report, we acknowledge that individual stakeholders may have unique demands. Thus, we offer customized report options that cater to your specific requirements. Our consultants are available to discuss your business requirements, and we can tailor the report's scope accordingly. Some of the common customizations that we are frequently requested to make by our clients include:

Free Sample TiO2 DongFang R5566 Titanium Dioxide

How do I know if a Unilever product contains titanium dioxide?

Founded in 1902 by Henrick J. Krebs, Krebs Pigments and Chemical Company produced lithopone, a widely used white paint pigment also manufactured by DuPont. But Krebs' company had another asset of special interest to DuPont. ...
Digestive System Exposure
Titanium Dioxide Raw Material Tio2 Powder


Matthew Wright, chair of the authority's working group on titanium dioxide, noted that the evidence for general toxic effects was not conclusive, but that the panel couldn't rule out genotoxicity entirely. There were also some current data limitations and the assessment could not establish a safe level for daily intake of the food additive, he stated.
The FDA has issued guidance clarifying the safe use of titanium dioxide pigment as a food colorant and has stated that titanium dioxide may be safely used in cosmetics, including those intended for use around the eye. FDA also regulates the safety and effectiveness of sunscreen active ingredients, including nanoscale titanium dioxide.
In addition to consistency, manufacturers must also consider the cost implications of buff percentage. Higher levels of coating on titanium dioxide particles can increase production costs, as more coating materials are required. However, a lower buff percentage may lead to a lower quality product that does not meet the needs of customers. Balancing the cost and quality considerations of buff percentage is a key challenge for manufacturers in the titanium dioxide industry.
The ingredient in question? Titanium dioxide.