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Titanium Dioxide: E171 no longer considered safe when used as a food additive by European Food Safety Authority, May 6, 2021
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While loose titanium dioxide presents a problem, titanium dioxide within sunscreen formulations presents a much safer option than conventional sunscreen chemicals like oxybenzone and octinoxate. However, titanium dioxide may become dangerous when it is nanoparticle size. Generally, nanoparticles can be 1000 times smaller than the width of a human hair. Despite nanoparticles becoming increasingly common across industries, they have not been properly assessed for human or environmental health effects, nor are they adequately regulated. Researchers don’t quite understand the impacts nanoparticles could have on human health and the environment. However, because of their infinitesimally small size, nanoparticles may be more chemically reactive and therefore more bioavailable, and may behave differently than larger particles of the same substance; these characteristics may lead to potential damage in the human body or ecosystem.
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Some consumer advocacy groups and health agencies — particularly, those at the Environmental Working Group — have been pushing federal officers at the Food and Drug Administration (FDA) to reconsider their existing rules on the additive, which is commonly found in processed snacks and sweets.
In 2022, a year after the EFSA recommended against the use of E171, the Food Standards Australia New Zealand (FSANZ) conducted its own reassessment of titanium dioxide as a food additive. The agency concluded that titanium dioxide was indeed safe to use as a food additive. The United Kingdom and Canada came to similar conclusions.


The FDA continues to allow for the safe use of titanium dioxide as a color additive in foods generally according to the specifications and conditions, including that the quantity of titanium dioxide does not exceed 1% by weight of the food, the FDA said in a statement to USA TODAY.
However, humans are not exposed to E171 in drinking water at any significant quantity over a long duration, so this potential effect is irrelevant to the human experience. It’s important to understand that a potential hazard is not the same thing as an actual risk.
Overall, the Food Directorate's comprehensive review of the available science of TiO2 as a food additive showed:
This classification was given, as some animal studies found that inhaling titanium dioxide dust might cause the development of lung tumors. However, IARC concluded that food products containing this additive do not pose this risk (11).
There are two primary forms of titanium dioxide commercially available: anatase and rutile. The rutile form is typically used in sunscreens due to its superior ability to handle UV rays and stability in the presence of UV light. The anatase form is typically used in other types of products, such as paint. Another plus of the rutile form is that its UVA protection extends past 400 nanometers, which is the upper limit of UVA.