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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon. There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”
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Titanium dioxide is used in the production of paper and textiles to improve whiteness, brightness, opacity and durability. It’s often used in fabrics, yarns, paper and other fibers.
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Lithopone, a white pigment composed of a mixture of barium sulfate and zinc sulfide, is commonly used in the leather industry as a coloring agent
. Leather suppliers around the world rely on lithopone to achieve the desired color and finish on their products.
Lithopone 30%, in any type of rubber, not only reduces the cost of partial substitution of TiO2 but also increases industrial production and improves the durability and the thermal and mechanical resistance of the finished product.
EFSA Scientific Conclusion on E171
THE OBSCURE HISTORY OF A UBIQUITOUS PIGMENT: PHOSPHORESCENT LITHOPONE AND ITS APPEARANCE ON DRAWINGS BY JOHN LA FARGE


A Lawsuit Claims Skittles Are Unfit for Consumption. Experts Weigh in, by Rachel Rabkin Peachman, The New York Times, July 26, 2022
To put this all into context maybe we should go back to the beginning & Bluescope steel who make all of our lovely Australian colour bond iron roofs.

titanium dioxide used for white pigments. The pigment helps to create a bright white surface that enhances the visual appeal of printed materials, making them more attractive and professional-looking. TiO2 is also used in the production of inkjet papers and photo printing papers to achieve high-quality images with sharp colors and fine details.
Overall, the Food Directorate's comprehensive review of the available science of TiO2 as a food additive showed: