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A 2012 study published in the journal Environmental Science & Technology noted that children are especially exposed to titanium dioxide because of the food that contains the food additive and is particularly marketed to children, including candy and cakes.

Titanium dioxide is produced in two main forms. The primary form, comprising over 98 percent of total production, is pigment grade titanium dioxide. The pigmentary form makes use of titanium dioxide’s excellent light-scattering properties in applications that require white opacity and brightness. The other form in which titanium dioxide is produced is as an ultrafine (nanomaterial) product. This form is selected when different properties, such as transparency and maximum ultraviolet light absorption, are required, such as in cosmetic sunscreens.

In 2022, a year after the EFSA recommended against the use of E171, the Food Standards Australia New Zealand (FSANZ) conducted its own reassessment of titanium dioxide as a food additive. The agency concluded that titanium dioxide was indeed safe to use as a food additive. The United Kingdom and Canada came to similar conclusions.

A number of our toothpastes do not contain titanium dioxide, including some of our Signal products (Signal Bio, Signal Nature Element, Signal White System, Signal Kids (Baby & Junior), Signal White Now Detox, Signal Anti-Cavity), Love Beauty and Planet and Schmidt’s Naturals.

The National Cancer Institute tested TiO₂ for possible carcinogenicity by the oral route of exposure by feeding rats and mice with TiO₂ (size not specified) at doses 25,000 or 50,000 ppm TiO₂ for 103 weeks. They concluded that TiO₂ was not carcinogenic.Also, the study with rats fed diets containing up to 5 % TiO₂ coated mica for 130 weeks showed no treatment-related carcinogenicity. Since the size and other TiO₂ properties were not specified or determined, we cannot generalize this conclusion and we have to take into account other possible outcomes of this scenario in different exposure conditions (other size/crystalline structure of TiO₂ etc.).

Fig. 9. Selected images of damaged skin treated with P25TiO₂NPs 10% (left) and healthy skin treated with VitaminB2@P25TiO₂NPs 10% (right).

We are a titanium dioxide manufacturer from China, our company has a perfect production capacity supporting, the main business is CR-930 series, anatase titanium dioxide BA01-01, CA100 series, Litho series, products with strong thickness resistance, good dispersion, high coverage. Widely used in paint, paper, rubber, coatings, tires, ceramics and other industries. Welcome your communication, negotiation and cooperation.
The company's main CR-930 series, Anatase titanium dioxide BA01-01, CA100 series, Lide powder series, has a professional management team, advanced production equipment and excellent technical advantages. The quality of our products is guaranteed and can also meet the manufacturing needs of different customers.
The factory is different from the dealer, we only provide FOB price of Tianjin port for the time being, we do not support CIF price for the time being, please understand. If necessary, the factory will provide you with quotation.
I'm Mia from Hebei Caiqing New Material Technology Co., LTD. My telephone number is +86 15694839000. My email address is sales02@cqtitaniumdioxide.com. We look forward to establishing long-term cooperative relations with your company.

According to data released by the China Coatings Industry Association, the total production of China's coatings industry has increased from 12.72 million tons in 2012 to 24.388 million tons in 2019, with a compound annual growth rate of 9.7%. Coatings, as an intermediate commodity, are closely related to downstream consumer markets such as the automotive industry, real estate, infrastructure, and home furnishings.

In a review published in 2022 in the journal Archives of Toxicology, researchers found that the ingestion of E171 is a “a definite health risk for consumers and their progeny.” After reviewing dozens of in vivo, ex vivo and in vitro studies on the toxicity of E171, the researchers wrote that two facts must be noted: “First, reprotoxicity studies show that animals of both sexes are impacted by the toxicity of these nanoparticles, underlining the importance of conducting in vivo studies using both male and female animals. Second, human exposure begins in utero via maternal-fetal transfer and continues after birth by breastfeeding. Children are then chronically re-exposed due to their food preferences. To be relevant to the human in vivo situation, experimental studies should therefore consider nanoparticle exposure with respect to the age or life period of the studied population.”

Titanium dioxide is added to some food packaging to preserve the shelf life of a product.